4670883Current and Future Developments in Physiology Volume: 1https://www.gandhi.com.mx/current-and-future-developments-in-physiology-volume--1-9781681083650/phttps://gandhi.vtexassets.com/arquivos/ids/4321895/image.jpg?v=63844664499843000013141825MXNBentham Science PublishersInStock/Ebooks/Plasticity in insulin-producing cells (?-cells) of the pancreas is a major contributor to metabolic control. Targeted regeneration of pancreatic ?-cells for the reversal of diabetes (by optimizing ?-cells mass and proliferation to meet metabolic requirements and counter autoimmune response) is still a theoretical intervention. This monograph reviews the biology, ontogeny, capabilities, and present practical limitations of ?-cell plasticity. Relevant biochemical pathways are described with the inclusion of information about how they change with aging, during pregnancy, and with diet. Readers will learn the following key aspects about ?-cell plasticity: -current knowledge of pancreatic ?-cells development, and how ?-cell mass and proliferation change throughout the human lifespan -the mechanisms responsible for ?-cell plasticity, based on animal models and clinical studies revealing environmental, epigenetic, endocrine and paracrine regulators -the therapeutic potential of resident stem cells within the pancreas / bone marrow and ?-cell progenitors This monograph is essential reading for researchers interested in updated knowledge about the molecular and cellular biology of ?-cells in the quest to find a reliable therapy for diabetes....4422324Current and Future Developments in Physiology Volume: 113141825https://www.gandhi.com.mx/current-and-future-developments-in-physiology-volume--1-9781681083650/phttps://gandhi.vtexassets.com/arquivos/ids/4321895/image.jpg?v=638446644998430000InStockMXN99999DIEbook20169781681083650_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_Plasticity in insulin-producing cells (?-cells) of the pancreas is a major contributor to metabolic control. Targeted regeneration of pancreatic ?-cells for the reversal of diabetes (by optimizing ?-cells mass and proliferation to meet metabolic requirements and counter autoimmune response) is still a theoretical intervention. This monograph reviews the biology, ontogeny, capabilities, and present practical limitations of ?-cell plasticity. Relevant biochemical pathways are described with the inclusion of information about how they change with aging, during pregnancy, and with diet. Readers will learn the following key aspects about ?-cell plasticity: -current knowledge of pancreatic ?-cells development, and how ?-cell mass and proliferation change throughout the human lifespan -the mechanisms responsible for ?-cell plasticity, based on animal models and clinical studies revealing environmental, epigenetic, endocrine and paracrine regulators -the therapeutic potential of resident stem cells within the pancreas / bone marrow and ?-cell progenitors This monograph is essential reading for researchers interested in updated knowledge about the molecular and cellular biology of ?-cells in the quest to find a reliable therapy for diabetes.(*_*)9781681083650_Plasticity in insulin-producing cells (?-cells) of the pancreas is a major contributor to metabolic control. Targeted regeneration of pancreatic ?-cells for the reversal of diabetes (by optimizing ?-cells mass and proliferation to meet metabolic requirements and counter autoimmune response) is still a theoretical intervention. This monograph reviews the biology, ontogeny, capabilities, and present practical limitations of ?-cell plasticity. Relevant biochemical pathways are described with the inclusion of information about how they change with aging, during pregnancy, and with diet. Readers will learn the following key aspects about ?-cell plasticity: -current knowledge of pancreatic ?-cells development, and how ?-cell mass and proliferation change throughout the human lifespan -the mechanisms responsible for ?-cell plasticity, based on animal models and clinical studies revealing environmental, epigenetic, endocrine and paracrine regulators -the therapeutic potential of resident stem cells within the pancreas / bone marrow and ?-cell progenitors This monograph is essential reading for researchers interested in updated knowledge about the molecular and cellular biology of ?-cells in the quest to find a reliable therapy for diabetes....9781681083650_Bentham Science Publisherslibro_electonico_9781681083650_9781681083650David .InglésMéxicohttps://getbook.kobo.com/koboid-prod-public/benthamscience-epub-e7b18953-124a-41f1-8d94-f46b49a0b527.epub2016-12-02T00:00:00+00:00Bentham Science Publishers