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Overcoming Resistance to EGFR Inhibitors in EGFR-Mutant NSCLC
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2042199Overcoming Resistance to EGFR Inhibitors in EGFR-Mutant NSCLChttps://www.gandhi.com.mx/overcoming-resistance-to-egfr-inhibitors-in-egfr-mutant-nsclc/phttps://gandhi.vtexassets.com/arquivos/ids/1261346/dbce135c-c6cb-4acc-997a-6fa7eeb2b7cc.jpg?v=638337731725100000https://gandhi.vtexassets.com/arquivos/ids/1260721/dbce135c-c6cb-4acc-997a-6fa7eeb2b7cc.jpg?v=63833773051963000020932326MXNAcademic PressInStock/Ebooks/<p>Overcoming Resistance to EGFR Inhibitors in EGFR Mutant NSCLC presents updated information on how EGFR mutant lung cancers evolve to evade EGFR inhibitors, clinical strategies that identify these mechanisms, and how to implement newer therapeutic strategies to combat resistance and improve patient survival. As resistance to EGFR inhibitors is often through re-activation of MEK/ERK and PI3K pathways, or through loss of cell death responses, there is much overlap with resistance to targeted therapies in other paradigms, such as BRAF inhibitors in BRAF mutant melanoma, and HER2 inhibitors in HER2 amplified breast cancer. This book is a valuable resource for cancer researchers, clinicians, graduate students and other members of the biomedical field who are interested in promising treatments for lung cancer. - Presents historical context on how NSCLC and SCLC has been treated, with an emphasis on NSCLC and how the concept of EGFR inhibitors has been implemented - Discusses critical resistant mechanisms seen in the clinic to 1st, 2nd and 3rd generation EGFR inhibitors - Encompasses the current state of affairs in clinical trials to address resistance</p>...2002514Overcoming Resistance to EGFR Inhibitors in EGFR-Mutant NSCLC20932326https://www.gandhi.com.mx/overcoming-resistance-to-egfr-inhibitors-in-egfr-mutant-nsclc/phttps://gandhi.vtexassets.com/arquivos/ids/1261346/dbce135c-c6cb-4acc-997a-6fa7eeb2b7cc.jpg?v=638337731725100000https://gandhi.vtexassets.com/arquivos/ids/1260721/dbce135c-c6cb-4acc-997a-6fa7eeb2b7cc.jpg?v=638337730519630000InStockMXN99999DIEbook20239780128228340_W3siaWQiOiJjMjkyNjk0Mi04N2NmLTRmYjEtYjg2Yy1iNTNmZmViYWYzYzEiLCJsaXN0UHJpY2UiOjIzMjYsImRpc2NvdW50IjoyMzMsInNlbGxpbmdQcmljZSI6MjA5MywiaW5jbHVkZXNUYXgiOnRydWUsInByaWNlVHlwZSI6Ildob2xlc2FsZSIsImN1cnJlbmN5IjoiTVhOIiwiZnJvbSI6IjIwMjUtMDEtMDhUMTU6MDA6MDBaIiwicmVnaW9uIjoiTVgiLCJpc1ByZW9yZGVyIjpmYWxzZX1d9780128228340_<p><em>Overcoming Resistance to EGFR Inhibitors in EGFR Mutant NSCLC</em> presents updated information on how EGFR mutant lung cancers evolve to evade EGFR inhibitors, clinical strategies that identify these mechanisms, and how to implement newer therapeutic strategies to combat resistance and improve patient survival. As resistance to EGFR inhibitors is often through re-activation of MEK/ERK and PI3K pathways, or through loss of cell death responses, there is much overlap with resistance to targeted therapies in other paradigms, such as BRAF inhibitors in BRAF mutant melanoma, and HER2 inhibitors in HER2 amplified breast cancer.</p><p>This book is a valuable resource for cancer researchers, clinicians, graduate students and other members of the biomedical field who are interested in promising treatments for lung cancer.</p><ul><li>Presents historical context on how NSCLC and SCLC has been treated, with an emphasis on NSCLC and how the concept of EGFR inhibitors has been implemented</li><li>Discusses critical resistant mechanisms seen in the clinic to 1st, 2nd and 3rd generation EGFR inhibitors</li><li>Encompasses the current state of affairs in clinical trials to address resistance</li></ul>...(*_*)9780128228340_<p>Overcoming Resistance to EGFR Inhibitors in EGFR Mutant NSCLC presents updated information on how EGFR mutant lung cancers evolve to evade EGFR inhibitors, clinical strategies that identify these mechanisms, and how to implement newer therapeutic strategies to combat resistance and improve patient survival. As resistance to EGFR inhibitors is often through re-activation of MEK/ERK and PI3K pathways, or through loss of cell death responses, there is much overlap with resistance to targeted therapies in other paradigms, such as BRAF inhibitors in BRAF mutant melanoma, and HER2 inhibitors in HER2 amplified breast cancer. This book is a valuable resource for cancer researchers, clinicians, graduate students and other members of the biomedical field who are interested in promising treatments for lung cancer. - Presents historical context on how NSCLC and SCLC has been treated, with an emphasis on NSCLC and how the concept of EGFR inhibitors has been implemented - Discusses critical resistant mechanisms seen in the clinic to 1st, 2nd and 3rd generation EGFR inhibitors - Encompasses the current state of affairs in clinical trials to address resistance</p>...9780128228340_Elsevier Science(*_*)9780128228340_Academic Presslibro_electonico_b7296fdb-6cad-3038-bb66-29f3fb6c4e5a_9780128228340;9780128228340_9780128228340InglésMéxicoAcademic Presshttps://getbook.kobo.com/koboid-prod-public/elsevierrefmonographs-epub-c648e3a6-8dc6-4122-90e4-5b6ee3854ae4.epub2023-01-30T00:00:00+00:00