?Sherlock Holmes took his bottle from the corner of the mantelpiece, and his hypodermic syringe from its neat morocco case. With his long, white, nervous fingers he adjusted the delicate needle and rolled back his left shirtcuff...?The Sign of the Four (1890), also called The Sign of Four, is the second novel featuring Sherlock Holmes written by Sir Arthur Conan Doyle. Doyle wrote four novels and 56 stories starring the fictional detective.